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November 20, 2008

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CEI-100 Capillary Electrophoresis Interface for ICP-MS

CETAC Technologies in collaboration with Dr. Andreas Prange and Dr. Dirk Schaumloffel from the GKSS Research Center (Germany) has developed a simple, efficient and robust Capillary Electrophoresis (CE) interface for ICP-MS. The CEI-100 interface maintains the high resolving power of CE while utilizing the high sensitivity and multi-element capability of ICP-MS. Through the calculation of optimal fluid mechanical flow properties, the CEI-100 provides the following benefits:

  • Stable, high resolution
    electrophoretic separation
  • Independent optimization of
    electrophoretic and nebulizer flows
  • Low dead volume to preserve
    the high resolution of CE
  • Minimal dilution (make-up liquid flow
    rate of <10 µl/min)
  • Extremely low sample consumption
    (<1 µl/min)
  • Elimination of detrimental secondary
    laminar flows within the CE capillary
CEI-100 Picture


CEI-100 components include a specialized low-flow microconcentric nebulizer, spray chamber, connecting cross-piece fitting, and mounting stand. The mounting stand includes positions to hold buffer and rinse solutions.

CEI-100 nebulizer

A number of application areas for the CEI-100 are listed below. A list of references is available.

Applications

  • Metals in complex biomolecular systems
  • Gold-Drug metabolic pathways
  • Platinum-Protein interaction in chemotherapeutic research
  • Metallothioneine studies (e.g. in context with Alzheimer's disease)
  • Toxicological studies



Last updated 16 Jan 2008
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